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Clinical Pharmacology & Experimental Therapeutics Center

The center provides pharmaceutical expertise to conduct and support preclinical and clinical/translational trials, and postmarketing assessment of pharmaceutical drugs. The Clinical Pharmacology & Experimental Therapeutics Center consists of four core areas of focused research:

  • Pediatric Pharmacology Research & Development Core
  • Experimental Therapeutics Core
  • North Texas Clinical Pharmacology Cancer Core (funded in part by the Cancer Prevention and Research Institute of Texas)
  • Pharmacoepidemiology and Clinical Outcomes Core

 Primary areas of research focus:

  • Pharmacokinetics/Pharmacodynamics
  • Drug metabolism
  • Drug formulation and delivery
  • Biomarker identification
  • Chemical characterization
  • Pharmacoepidemiology and drug safety
  • Clinical Outcomes

Analytical Instrumentation:

The Center’s analytical laboratory specializes in developing and validating methods for the analysis of both small- and large-molecule pharmaceutical agents, their metabolites, and biomarkers in complex biologic matrices using state-of-the-art bioanalytical techniques.

 

Faculty Members:

 

Capabilities

Overall, the Clinical Pharmacology & Experimental Therapeutics Center specializes in conducting pharmacology studies on experimental therapeutics.

Specific capabilities of the Center include:

  • Conduct of Pharmacoepidemiology studies
  • Conduct of Clinical Outcomes studies
  • Bioanalytical method development
  • Bioanalytical method validation
  • Blood/Plasma/Serum sample analysis
  • Tissue sample analysis / tissue distribution analysis
  • Analyte/formulation stability studies
  • Automated sample preparation
  • Small molecule bioanalytical sample analysis
  • Biomolecule bioanalytical sample analysis
  • Metals analysis
  • Pharmacokinetic determinations
  • Targeted metabolite studies
  • Chemical characterization of small molecules, biotherapeutics, formulated products and botanical extracts
  • Regulatory development input

 Additional services provided by Center faculty:

  • Program and protocol development and support
  • Analyses and interpretation of PK and PK/PD data
  • Population PK analysis for optimal dosing

Facilities

  • Laboratory space: ~2,500 square feet
  • General equipment:  analytical balances, pipettes, pH meters, centrifuges, two Labconco CentriVap® systems, two Nitrogen-evaporation systems, two refrigerators (5 ± 3 °C), two freezers (-20 ± 10 °C) and four ultra-freezers (-80 ± 10 °C). The ultra-freezers are continuously monitored and clinical samples are inventoried using FreezerPro® software package. Specialized automated sample preparation equipment includes an Eppendorf EpMotion M5073 and a Tomtec Quadra 4® automated liquid handling systems.
  • Tissue preparation equipment: ProScientific DPS-20 homogenization system (ultrasonic and mechanical homogenization); Leica RM2255 microtome, Leica CM3050S Cryostat, and a Leica LMP6 laser microdissection system.
  • Mass spectrometric instrumentation includes: Sciex QTRAP® 6500+, Sciex QTRAP® 5500, Sciex TripleTOF™ 5600, and an Agilent 7700 ICP-MS. The Sciex QTRAP®and TripleTOF™instruments can be interfaced with Shimadzu Nexera UHPLC systems or Eksigent exspert™nano-LC/micro-LC system.  Additional gradient liquid chromatographic (HPLC) systems are available with Shimadzu UV/Vis, ELSD and Dionex electrochemical detectors. Specialized analytical software includes Sciex’s Anayst™, PeakView™, SWATH™, and MultiQuant™ software packages.
  • Pharmacokinetic modeling software: Cetara’s Phoenix 64 WinNonLin v6.4.



About:

Founded in 2004

Located in Dallas Medical District adjacent fo the UT Southwestern Medical Center

Dr. Trey Putnam

William "Trey" Putnam, Ph.D.
Center Director

(214) 358-9018

5920 Forest Park Rd Dallas, TX

Pricing:

Academic pricing is available for research collaborations where the investigators hold primary appointments with institutions of higher education. Due to external funding from the Cancer Prevention & Research Institute of Texas (CPRIT), special pricing is available to support cancer investigations.

Grant and Contract Funding:

Sustained since 2004

Funders: NIH, NICHD, NCI and others

North Texas Clinical Pharmacology Cancer Core: Significant funding has recently been awarded by the Cancer Prevention and Research Institute of Texas (CPRIT) to further develop the core (second 5-year award).

CTSA core facility