The CBC was formed in 1999 with common interests and goals shared by several faculty
members in the School of Pharmacy. The goal is to determine molecular mechanisms of
cancer malignancy with specific aims to develop advanced anti-cancer therapeutics
for effective clinical treatment.
Over the last 10 years, the CBC has significantly expanded into three major cancer
research areas: Chemoprevention, Cancer Biology, and Experimental Therapeutics. More
than 20 research grants with total support of >$10 million research dollars were obtained
from NIH, DOD, CPRIT, and other funding agencies. Currently, the CBC has more than
1.5 million dollars annually, which support various biomedical and pharmaceutical
research projects.This is a remarkable achievement reflecting the members’ effort
and dedication considering the current funding scenario.
Through intensive collaborative and innovative research, the CBC members have made
numerous discoveries and published more than 100 articles in highly peer-reviewed
journals including Cancer Research, Clinical Cancer Research, Oncogene, Molecular
Cancer Therapeutics, Molecular Cancer, Molecular Pharmaceutics, JBC, Carcinogenesis,
and other peer-reviewed journals. The CBC members also serve in various national committees,
such as NIH Study Sections, DOD grant review panels, various journal editorial boards,
and act as organizers & sections chairs for various local, national, and international
In summary the CBC is currently a vital research component in the School of Pharmacy
and a major research force in the TTU system wide cancer research community.
The mission of the Cancer Biology Research Center (CBC) is to advance understanding,
prevention, diagnosis, and treatment of cancer by generating new knowledge in cancer
biology and therapy and by participating in the application of this knowledge to translational
and clinical cancer research.
Based on members’ background and expertise, the CBC has been organized into three
project targeted units:
1) Cancer Chemoprevention: studying natural products and chemicals that potentially prevent tumor initiation
2) Cancer Biology & Pathogenesis: studying multi-signaling cascades that regulate cancer malignancy and phenotype.
3) Cancer Therapeutics & Therapy: developing potential anti-cancer therapeutics and studying mechanisms to overcome
cancer drug resistance.
The CBC also has an Advanced Cancer Cell Image/Analysis core.These advanced instruments
allow the CBC members and their associates in-depth analysis of molecular events occurred
during cancer progression and drug treatment.